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Quality of Life and Psychiatric Comorbidities in CKD Patients on Hemodialysis

Jivitesh Singh Chahal1, Pir Dutt Bansal1, Aman Bharti2

  • 1Department of Psychiatry, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India.

Journal of Pharmacy & Bioallied Sciences
|January 12, 2026
PubMed

Insights

Psychiatric comorbidities like depression and anxiety are common in hemodialysis patients, significantly reducing their quality of life across all domains. This highlights a critical need for integrated mental health care in nephrology settings.

Area of Science:

  • Nephrology
  • Psychiatry
  • Public Health

Background:

  • Chronic kidney disease (CKD) patients on hemodialysis (HD) often experience significant psychological distress.
  • Understanding the prevalence and impact of psychiatric comorbidities is crucial for comprehensive patient care.

Purpose of the Study:

  • To determine the prevalence of psychiatric comorbidities in hemodialysis patients.
  • To evaluate the impact of these comorbidities on the quality of life (QOL) of hemodialysis patients.

Main Methods:

  • An observational, cross-sectional study involving 96 hemodialysis patients.
  • Utilized psychiatric history, Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), and WHOQOL-BREF for assessments.
  • Statistical analysis performed using SPSS v25, with significance set at P < 0.05.

Main Results:

  • Psychiatric comorbidities were identified in 64.58% of patients, with 46.77% having both depression and anxiety.
  • Patients with comorbidities exhibited significantly lower QOL scores across physical, psychological, social, and environmental domains (P < 0.0001).
  • Strong positive correlation between HAM-D and HAM-A scores (ρ = 0.522) and strong negative correlations with all WHO QOL domains (ρ from -0.702 to -0.811).

Conclusions:

  • High prevalence of psychiatric comorbidities, especially depression and anxiety, in hemodialysis patients.
  • These comorbidities significantly impair the quality of life in this population.
  • Integrated mental health support is essential for improving outcomes in CKD patients undergoing hemodialysis.
Abstract

Keywords:
Anxietydepressionkidney failurequality of liferenal dialysisrisk factors

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