All-comEr Registry of OCT (AERO) to Investigate the MLD-MAX Algorithm for OCT-guided-precision-PCI in Daily Routine:...

Area of Science:

• Cardiovascular medicine
• Interventional cardiology
• Medical imaging technology

Background:

• Optical coherence tomography (OCT) is recommended for percutaneous coronary intervention (PCI) but faces limited adoption.
• Randomized controlled trials demonstrate OCT's clinical benefits under strict protocols, yet real-world performance remains unclear.

Purpose of the Study:

• To evaluate the real-world application of the MLD-MAX algorithmic approach for OCT-guided PCI.
• To compare the outcomes of OCT-guided PCI using the MLD-MAX algorithm with data from the ILUMIEN-IV randomized controlled trial.
• To explore the role of OCT in diagnosing acute coronary syndrome and guiding drug-coated balloon PCI.

Main Methods:

• Prospective, multicentre registry (ILUMIEN-V-AERO) enrolling 2,000 patients across the UK, Germany, and Saudi Arabia.
• Primary endpoint: post-PCI minimum stent area relative to reference segments.
• Secondary endpoints include OCT imaging assessments, procedural outcomes, and clinical endpoints such as target lesion failure at 30 days and 6 months.

Main Results:

• This section is not applicable as the study is prospective and data is still being collected.

Conclusions:

• The ILUMIEN-V-AERO registry is a large, prospective study designed to evaluate the real-world performance of OCT in guiding PCI.
• Findings will provide insights into the effectiveness of the MLD-MAX algorithm and OCT's utility in underexplored areas of PCI guidance.