A Tertiary Care Hospital's Antimicrobial Sensitivity Pattern and Microorganism Spectrum
Sourabh Kumar Tiwari1, Mansi Gupta1, Neelu Jain1
1Department of Microbiology, Bundelkhand Government Medical College, Sagar, Madhya Pradesh, India.
Journal of Pharmacy & Bioallied Sciences
|January 12, 2026
Summary
Antimicrobial resistance is a major threat. This study found common bacteria like E. coli and S. aureus, with high rates of Methicillin-resistant Staphylococcus aureus (MRSA) and resistance in Gram-negative bacteria.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Public Health
Background:
- Antimicrobial resistance (AMR) poses a significant global health challenge, particularly in hospitals.
- Effective empirical treatment relies on understanding local pathogen prevalence and resistance trends.
Purpose of the Study:
- To identify microorganisms in clinical samples and their susceptibility to antibiotics.
- To assess antimicrobial resistance patterns in a tertiary care hospital setting.
Main Methods:
- Cross-sectional observational study over two years.
- Standard microbiological techniques for specimen analysis.
- Antimicrobial susceptibility testing following CLSI guidelines.
Main Results:
- 85.6% of 4,216 samples yielded microbial growth.
- Escherichia coli (26.3%) and Staphylococcus aureus (17.0%) were the most frequent isolates.
- High prevalence of Methicillin-resistant Staphylococcus aureus (MRSA) (62.3%) and significant multidrug resistance (MDR) and ESBL production in Gram-negative bacteria.
Conclusions:
- Regular antibiogram surveillance is essential.
- Implementing robust antimicrobial stewardship programs is critical to combat resistance.
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