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Updated: Jan 13, 2026
Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
Comparative Evaluation of Platelet-Rich Fibrin (PRF) versus Collagen Membrane in Accelerating Healing after
1Department of Dentistry, Krishna Nagar Institute of Medical Sciences, Nadia, Krishna Nagar, West Bengal, India.
Background:
Removing impacted third molars in the lower jaw can often cause problems, such as pain, swelling, and slow regrowth of tissue. Postoperative healing is often improved using platelet-rich fibrin (PRF) and collagen membranes.
Materials And Methods:
Sixty patients needing the removal of bilateral mandibular third molars were randomly assigned to the two groups (30 patients in each group). Group A used PRF put into the extraction socket, and Group B placed a collagen membrane. Pain (based on visual analog scale), swelling (measured), and soft tissue healing (using the Landry's healing index) were compared on the 3rd, 7th, and 14th postoperative days. Researchers used SPSS version 25.0 with a significance of P < 0.05.
Results:
On the third day, the pain score was lower on average in the PRF group (3.2) than in the collagen group (4.5). In Group A, the swelling was lower (4.1 ± 0.6 mm) compared to Group B (5.6 ± 0.9 mm). By the fourteenth day, tissues in the PRF group (4.6 ± 0.4) scored higher for healing, proving they healed faster compared to the collagen group (3.9 ± 0.6) (P < 0.01). Everyone involved in the study reported no negative experiences.
Conclusion:
During the first few days after having third molar teeth removed, patients who used PRF experienced better pain management, a reduction in swelling, and swifter healing of the tissues than those who used collagen membranes.
