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Evaluation of Mandibular Cortical Bone Density Changes Using CBCT During Accelerated Orthodontics with Low-Level
Mohammed E Rashid1, Tarek Ibrahim1, Andullah A Ghani1
1Department of Oral and Maxillofacial Diagnostic Sciences, College of Dentistry, Taibah University, Al Madinah Al Munawara, Saudi Arabia.
Journal of Pharmacy & Bioallied Sciences
|January 12, 2026
Summary
Low-level laser therapy (LLLT) during orthodontic treatment significantly reduces mandibular bone density. This finding suggests LLLT may accelerate tooth movement by altering bone structure.
Area of Science:
- Orthodontics and Dental Implantology
- Biomedical Engineering
- Bone Physiology
Background:
- Accelerated orthodontics aims to reduce treatment duration.
- Low-level laser therapy (LLLT) is explored as an adjunct to speed up tooth movement.
- The effect of LLLT on mandibular cortical bone density during orthodontic treatment is not well understood.
Purpose of the Study:
- To investigate the impact of LLLT on mandibular cortical bone density in patients undergoing orthodontic treatment.
- To assess changes in bone density using cone-beam computed tomography (CBCT).
Main Methods:
- A prospective randomized controlled study involved 40 patients (18-30 years) divided into LLLT and control groups.
- The LLLT group received diode laser irradiation (808 nm) on alternate days for one month.
- CBCT scans were taken at baseline and after 12 weeks to measure cortical bone density in the mandibular first molar and canine regions.
Main Results:
- The LLLT group showed a significant reduction in mandibular cortical bone density at both molar and canine sites after 12 weeks (P < 0.05).
- The control group exhibited minimal and non-significant changes in bone density.
- Intergroup comparison revealed significantly lower bone density in the LLLT group compared to the control group at 12 weeks.
Conclusions:
- LLLT significantly reduces mandibular cortical bone density during orthodontic treatment.
- This reduction in bone density may contribute to accelerated tooth movement.
- CBCT is a reliable imaging tool for evaluating in vivo bone changes during orthodontic interventions.

