Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sleep apnea physiology and MRI-enlarged perivascular spaces in community-dwelling adults.

Sleep medicine·2026
Same author

Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

The Canadian multi-ethnic research on aging (CAMERA) study: Design, participant characteristics, and preliminary findings.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

A deep learning pipeline for mapping in situ network-level neurovascular coupling in multi-photon fluorescence microscopy.

eLife·2026
Same author

Fetal developmental trajectories following maternal immune activation are shaped by sex chromosome-gonadal interactions.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Neuroimaging in lesioning therapy for obsessive-compulsive disorder: region-based and network analysis of preoperative outcome predictors and postoperative effects.

NeuroImage. Clinical·2026
Same journal

Measurement prediction and power analysis for fNIRS and DOT.

Imaging neuroscience (Cambridge, Mass.)·2026
Same journal

Individualized mapping of functional brain networks in older adulthood.

Imaging neuroscience (Cambridge, Mass.)·2026
Same journal

Is the whole more than the sum of its parts? Considering global and local features of the connectome improves prediction of individuals and phenotypes.

Imaging neuroscience (Cambridge, Mass.)·2026
Same journal

The language network responds robustly to sentences across tasks.

Imaging neuroscience (Cambridge, Mass.)·2026
Same journal

Neighborhood disadvantage and brain myelination: Insights from infancy to childhood.

Imaging neuroscience (Cambridge, Mass.)·2026
Same journal

Meditation and neurofeedback: A systematic scoping review, synthesis, and future directions.

Imaging neuroscience (Cambridge, Mass.)·2026
See all related articles

Related Experiment Video

Updated: Jan 13, 2026

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

3.2K

Parametrizing alternating current stimulation for neuromodulation.

Monica Bell Vila1,2, Margaret Koletar2, Adrienne Dorr2

  • 1Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

Imaging Neuroscience (Cambridge, Mass.)
|January 12, 2026
PubMed
Summary
This summary is machine-generated.

Alternating current stimulation (ACS) modulates neuronal activity based on frequency and amplitude. This neuromodulation, particularly neuronal entrainment, can persist after stimulation, offering pathways for treatment optimization.

Keywords:
in situ electrophysiologyneuromodulationtranscranial alternating current stimulation

More Related Videos

Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness
04:04

Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness

Published on: July 11, 2025

1.3K
Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
07:47

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Published on: February 4, 2016

13.6K

Related Experiment Videos

Last Updated: Jan 13, 2026

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

3.2K
Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness
04:04

Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness

Published on: July 11, 2025

1.3K
Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
07:47

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Published on: February 4, 2016

13.6K

Area of Science:

  • Neuroscience
  • Biomedical Engineering

Background:

  • Clinical use of alternating current stimulation (ACS) is limited by varied patient responses.
  • Optimizing ACS requires understanding neuronal responses to stimulation parameters.

Purpose of the Study:

  • Characterize neuronal responses to varying ACS frequencies and amplitudes.
  • Assess the persistence of neuronal activity changes post-stimulation for neuromodulation.
  • Inform ACS optimization pathways.

Main Methods:

  • Subcutaneous ACS delivered to adult rats with concurrent intracortical electrophysiological recording.
  • Analysis of spiking activity, power spectra, and low-frequency to high-frequency phase-amplitude coupling (LF-HF PAC).
  • ACS applied for 1 or 20 minutes.

Main Results:

  • Both ACS durations modulated neuronal firing patterns (rate or entrainment) in a frequency- and amplitude-dependent manner.
  • Increased ACS amplitude/frequency enhanced neuronal entrainment, which persisted post-stimulation.
  • Neuronal entrainment correlated with decreased power and LF-HF PAC, suggesting functional reorganization potential.

Conclusions:

  • ACS can modulate neuronal activity, with entrainment being a key factor for sustained neuromodulation.
  • High-frequency ACS shows potential for facilitating signal integration and functional reorganization.
  • Low-frequency ACS may reduce hypersynchronous activity by increasing spike timing variability.