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Fermented Rice Bran: A Promising Therapeutic Agent Against High-Fat Diet-Induced Metabolic Disorders.

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This summary is machine-generated.

Fermented rice bran (FRB) improves nutritional quality and combats high-fat diet effects. FRB supplementation in rats reduced weight gain, blood glucose, liver fat, and improved liver morphology, suggesting its therapeutic potential for metabolic diseases.

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Area of Science:

  • Nutritional Science
  • Metabolic Health
  • Food Science

Background:

  • High-fat diets (HFD) promote metabolic diseases like obesity and fatty liver.
  • Natural dietary interventions are needed to manage these HFD-induced conditions.
  • Rice bran, a nutrient-rich byproduct, offers potential therapeutic benefits.

Purpose of the Study:

  • To analyze the composition of fermented rice bran (FRB) and nonfermented rice bran (NFRB).
  • To evaluate the effects of FRB on HFD-induced obesity in rats.
  • To explore FRB's impact on metabolic parameters, gene expression, and liver health.

Main Methods:

  • Solid-phase fermentation optimized rice bran composition.
  • HFD-induced obese rats were supplemented with FRB for 8 weeks.
  • Body weight, blood glucose, liver fat, lipid profiles, gene expression, and liver histology were assessed.

Main Results:

  • Fermentation enhanced rice bran's nutritional and antioxidant properties.
  • FRB supplementation reduced body weight gain (3.5%), blood glucose (2.03 mmol/L), and liver fat accumulation.
  • FRB improved cognitive function, lipid profiles, and liver morphology by reducing inflammation and necrosis.

Conclusions:

  • Optimized fermented rice bran (FRB) possesses improved nutritional and antioxidant qualities.
  • FRB effectively mitigates HFD-induced metabolic dysfunction in rats.
  • FRB demonstrates significant potential for preventing and treating lifestyle-related diseases.