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Related Experiment Video

Updated: Jan 13, 2026

Laparoscopic Anatomical Right Hemihepatectomy via the In Situ Anterior Approach
05:30

Laparoscopic Anatomical Right Hemihepatectomy via the In Situ Anterior Approach

Published on: August 8, 2025

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Giant Primary Hepatic Endodermal Sinus Tumor: Multidisciplinary Management and Long-Term Survival.

Katia Roque1,2,3, Rossana Ruiz1, Renier Cruz4

  • 1Department of Medical Oncology, National Institute of Neoplastic Diseases (INEN), Lima, Peru.

Case Reports in Oncological Medicine
|January 12, 2026
PubMed
Summary

Primary hepatic endodermal sinus tumors (ESTs), or yolk sac tumors, are rare but treatable. This case highlights successful management of a hepatic EST mimicking HCC, achieving long-term survival with chemotherapy.

Keywords:
alpha-fetoproteincase reportextragonadal germ cellprimary hepatic endodermal sinus tumor

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Endodermal sinus tumors (ESTs), also known as yolk sac tumors, are a type of germ cell tumor.
  • While typically gonadal, 1%-5% of ESTs occur extragonadally, with primary hepatic EST being exceptionally rare.

Purpose of the Study:

  • To present a case of primary hepatic endodermal sinus tumor (EST) in a young woman.
  • To discuss the diagnostic challenges and successful management of this rare condition.

Main Methods:

  • Case report of a 34-year-old woman with a hepatic mass and elevated alpha-fetoprotein (AFP).
  • Initial misdiagnosis as hepatocellular carcinoma (HCC) leading to surgery.
  • Post-operative chemotherapy (BEP and EP) and follow-up imaging (PET CT).

Main Results:

  • Pathology confirmed primary hepatic EST after hepatectomy.
  • Chemotherapy resulted in a complete response, with no evidence of disease at over 5 years.
  • The patient remains clinically stable with negative tumor markers.

Conclusions:

  • Primary hepatic EST is a rare but crucial differential diagnosis for hepatic masses, especially in young women with elevated AFP.
  • Early biopsy and multidisciplinary care are vital for managing this chemosensitive tumor.
  • Timely systemic treatment can lead to long-term survival.