Quantitative Diffusion and Perfusion MRI as Response Predictor in Cervical Squamous Cell Carcinoma Treated with CCRT

Area of Science:

• Oncology
• Radiology
• Medical Imaging

Background:

• Locally advanced cervical squamous cell carcinoma (LASCC) requires effective treatment monitoring.
• Chemoradiotherapy (CCRT) is a standard treatment for LASCC.
• Predicting treatment response is crucial for patient management.

Purpose of the Study:

• To evaluate the treatment response to chemoradiotherapy in LASCC.
• To assess the role of quantitative diffusion-weighted imaging (DWI) and perfusion MRI parameters as response predictors.

Main Methods:

• Included patients with LASCC undergoing CCRT.
• Performed pre- and post-CCRT diffusion-weighted imaging (DWI) and perfusion MRI.
• Analyzed quantitative DWI (apparent diffusion coefficient [ADC]) and perfusion MRI parameters (Ktrans, Kep, Ve, Vp, SImax, SIrel, time-to-peak).

Main Results:

• MR perfusion parameters (except Vp) showed statistically significant results (p < 0.05) in evaluating CCRT response.
• Pretreatment Kep demonstrated the highest diagnostic performance (sensitivity 100%, specificity 80%, AUC 0.833).
• ADC values did not show significant results for treatment response evaluation.

Conclusions:

• Quantitative MR perfusion parameters play a significant role in evaluating treatment response to CCRT in LASCC.
• Perfusion MRI parameters are valuable tools for predicting CCRT outcomes in LASCC.