Related Experiment Video

Updated: Jan 13, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

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Comparison of Dual-Energy CT Derived Myocardial Delayed Enhancement with Magnetic Resonance Imaging in Patients with

Damandeep Singh1, Uma Debi1, Manphool Singhal1

  • 1Department of Radiology and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

The Indian Journal of Radiology & Imaging
|January 12, 2026
PubMed

Insights

Dual energy cardiac computed tomography (DECT) can diagnose coronary artery disease and myocardial fibrosis in a single investigation. This method shows comparable performance to cardiac magnetic resonance imaging (CMRI) for detecting myocardial fibrosis.

Area of Science:

  • Cardiology
  • Radiology
  • Medical Imaging

Background:

  • Cardiomyopathy (CMP) and heart failure (HF) are leading causes of death.
  • Late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMRI) detects myocardial fibrosis.
  • Increasing ischemia-related heart failure necessitates improved diagnostics for coronary artery disease (CAD).

Purpose of the Study:

  • To evaluate Dual energy cardiac computed tomography (DECT) for diagnosing CAD and myocardial fibrosis.
  • To assess DECT's diagnostic performance for myocardial delayed enhancement (MDE).
  • To compare DECT findings with LGE on CMRI as the reference standard.

Main Methods:

  • Thirty heart failure patients with LGE on CMRI underwent DECT.
  • DECT included coronary angiography and a delayed scan for MDE assessment.
  • MDE images (virtual monochromatic and iodine density maps) were compared to LGE images.

Main Results:

  • DECT's diagnostic accuracy for MDE was 76% (iodine density maps) and 66% (VM images) compared to LGE.
  • Sensitivity and specificity of VM images versus iodine density maps were 86.96% and 100%, respectively.
  • A kappa value of 0.757 indicated statistically significant results.

Conclusions:

  • DECT is a robust, single-step investigation for diagnosing CAD and myocardial fibrosis.
  • DECT demonstrates comparable performance to CMRI-derived LGE imaging.
  • DECT offers a valuable alternative for evaluating patients with heart failure and suspected myocardial fibrosis.
Abstract

Keywords:
cardiac magnetic resonancecardiomyopathydual energyheart failurelate gadolinium enhancementmyocardial delayed enhancement

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