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Updated: Jan 13, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
Published on: October 16, 2021
Transcatheter Mitral Valve Repair With MitraClip® in a Heart Transplant Recipient: Pushing the Limits of Percutaneous
Pasquale Gagliardi1,2, Marco Ferlini1, Romina Frassica1
1Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, ITA.
Abstract:
We report the case of a 62-year-old female who developed severe symptomatic functional mitral regurgitation (MR) 18 years after heart transplantation. Given her extremely high surgical risk, transcatheter edge-to-edge mitral valve repair with the MitraClip® device was selected as the most appropriate therapeutic option. The procedure was technically challenging due to altered post-transplant anatomy, but it was completed successfully without immediate complications and resulted in a substantial reduction in regurgitation. During early follow-up, a small left atrial thrombus was identified and subsequently resolved after a six-week course of oral anticoagulation. This report illustrates the feasibility and safety of transcatheter mitral repair in carefully selected heart transplant recipients and underscores the importance of tailored post-procedural surveillance in this complex population.
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