An Atypical Case of Lactobacillus jensenii Discitis and Osteomyelitis
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View abstract on PubMed
Summary
This summary is machine-generated.Lactobacillus jensenii, typically harmless, caused rare severe spinal infection (discitis, osteomyelitis) in an immunocompromised patient. Diagnosis required advanced sequencing when standard cultures failed, highlighting a unique case of Lactobacillus infection.
Area Of Science
- Infectious Diseases
- Microbiology
- Clinical Case Study
Background
- Lactobacillus species are generally considered commensal and beneficial bacteria.
- Infections caused by Lactobacillus are rare, particularly in immunocompetent individuals.
- Severe invasive infections, such as osteomyelitis and discitis, are exceptionally uncommon.
Purpose Of The Study
- To report a rare case of Lactobacillus jensenii causing lumbosacral discitis and osteomyelitis.
- To highlight the diagnostic challenges in identifying Lactobacillus infections.
- To describe the successful treatment of a complex Lactobacillus infection.
Main Methods
- A case report of a 63-year-old female patient with severe spinal infection.
- Diagnosis was confirmed using next-generation sequencing on a lumbar biopsy.
- Conventional blood and tissue cultures were negative for microbial growth.
- Treatment involved a six-week course of piperacillin-tazobactam followed by amoxicillin-clavulanate.
Main Results
- Lactobacillus jensenii was identified as the causative agent of lumbosacral discitis and osteomyelitis.
- The infection was complicated by bilateral psoas abscesses and myositis.
- Next-generation sequencing provided a definitive diagnosis when standard cultures were unrevealing.
- The patient experienced a satisfactory clinical recovery with resolution of symptoms.
Conclusions
- Lactobacillus jensenii can cause severe invasive infections, even in the absence of significant immunocompromise.
- Advanced molecular techniques like next-generation sequencing are crucial for diagnosing rare microbial infections.
- Prompt and appropriate antibiotic therapy can lead to successful outcomes in complex Lactobacillus infections.
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