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Erythema Nodosum Leprosum Triggered by Herpes Simplex Infection: A Case Report
Usamah Al-Anbagi1, Abdulqadir J Nashwan2, Samir Al Hyassat3
1Department of Internal Medicine, Hamad Medical Corporation, Doha, QAT.
Cureus
|January 12, 2026
Summary
Erythema nodosum leprosum (ENL), a leprosy complication, can mimic other conditions. This case shows how a herpes simplex virus infection triggered ENL in a leprosy patient, emphasizing early diagnosis for effective treatment.
Area of Science:
- Dermatology
- Infectious Diseases
- Immunology
Background:
- Leprosy, caused by Mycobacterium leprae, is a chronic granulomatous disease affecting skin and nerves.
- Erythema nodosum leprosum (ENL), a type 2 lepra reaction, is an immunologic complication of lepromatous leprosy, characterized by nodules, fever, and inflammation.
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