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Updated: May 5, 2026

Author Spotlight: Detection and Treatment of Helicobacter pylori Infection
Published on: July 28, 2023
Retrospective Comparison of Conventional Triple Therapy and Levofloxacin-Based Sequential Therapy for Helicobacter
1Gastroenterology, Mardan Medical Complex, Mardan, PAK.
Objective:
This study aims to compare, using record-based data, the clearance proportions of the conventional triple management regimen and the levofloxacin-based sequential management regimen in patients treated at Mardan Medical Complex.
Methods:
A record-based review was conducted from January to June 2024 among adults aged 18 to 65 years with stool antigen-confirmed Helicobacter pylori infection. Data were collected for demographics, management regimens, and post-management stool antigen results. Statistical analyses included Chi-square and independent t-tests (p < 0.05 notable).
Results:
Among 238 patients, clearance was obtained in 62% of those receiving the triple management regimen and 80% of those receiving the sequential management regimen (χ² = 9.03, p = 0.003). The sequential management regimen showed greater clearance and better tolerance.
Conclusion:
Sequential management regimen obtained superior clearance proportions and should be preferred in areas with high clarithromycin resistance.
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