Clinical Anthropometry in Male Infertility: Differences Between Men With and Without Klinefelter Syndrome

Area of Science:

• Reproductive Endocrinology
• Human Genetics
• Anthropometry

Background:

• Klinefelter syndrome (KS) is a leading genetic cause of male infertility.
• KS is often associated with distinct anthropometric features.
• Limited comparative data exists for Japanese infertile men with and without KS.

Purpose of the Study:

• To investigate anthropometric differences, specifically arm span, between infertile men with and without KS in Japan.
• To assess the clinical utility of anthropometric measurements in diagnosing KS in infertile men.

Main Methods:

• A comparative study involving 30 infertile Japanese men with KS and 289 infertile men without KS.
• Data collection included age, height, weight, body mass index (BMI), and arm span.
• Patients were recruited from an outpatient male infertility clinic.

Main Results:

• Infertile men with KS exhibited significantly longer arm spans compared to the non-KS group (p=0.046).
• Height and weight were also significantly greater in the KS group (p=0.019 and p=0.017, respectively).
• Body mass index (BMI) did not show a significant difference between the groups.

Conclusions:

• Infertile Japanese men with KS demonstrate eunuchoid body proportions, characterized by a longer arm span.
• Routine anthropometric assessment, including arm span measurement, is clinically valuable for evaluating male infertility.
• These findings support the integration of anthropometric data into the diagnostic workup for male infertility.