Related Experiment Video
Updated: Jan 13, 2026

Author Spotlight: Advancing Human Ovarian Repair and Cancer Studies with Surface Epithelium Organoids
Published on: August 16, 2024
Fetal Ovarian Cyst Associated With Disorders of Sex Development: A Case Report
Ana Sofia Rosado-Guzmán1, Zaira Vanessa Escobedo-Enríquez1, Abril Adriana Arellano-Llamas2
1Obstetrics and Gynecology, Hospital de Gineco Obstetricia No. 3 "La Raza" Medicina Materno Fetal, Instituto Mexicano del Seguro Social, Mexico City, MEX.
None:
Ovarian cyst is a frequent abdominal tumor in female fetuses (1/2,600 live births), but its prenatal diagnosis can be challenging in the context of ambiguous genitalia. The most common cause of genital virilization in female fetuses is congenital adrenal hyperplasia (CAH), which results from the overproduction of androgen hormones. These hormones may influence the fetal ovary in a way comparable to polycystic ovarian syndrome (PCOS) in adults, leading to the development of an ovarian cyst that may regress. We present the case of a fetus prenatally diagnosed with a large ovarian cyst and ambiguous genitalia. After birth, a diagnosis of salt-wasting CAH was confirmed. A left salpingo-oophorectomy was performed, and histopathological examination revealed a simple follicular cyst.
Related Concept Videos
Oogenesis
Disorders of the Female Reproductive System
Sex-linked Disorders
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Development of the Sexual Organs in the Embryo and Fetus
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...

