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Early and Pronounced PVR Reaction After Revitrectomy With Allogeneic Platelet Concentrate in Persistent Macular Hole
Patrick C Fisel1, Martin Spitzer1, Aydin Özen1
1Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, uke.de.
Case Reports in Ophthalmological Medicine
|January 12, 2026
Summary
Two cases developed severe proliferative vitreoretinopathy (PVR) shortly after vitrectomy with allogeneic platelet concentrate (PC). This suggests allogeneic PC may be an etiological factor in PVR development, a rare complication.
Area of Science:
- Ophthalmology
- Regenerative Medicine
Background:
- Proliferative vitreoretinopathy (PVR) is a significant complication following retinal surgery.
- Vitrectomy with platelet concentrate (PC) is a standard procedure for persistent macular holes, typically using autologous PC.
Purpose of the Study:
- To report two unusual cases of rapid PVR development after vitrectomy with allogeneic PC.
- To investigate the potential role of allogeneic PC in PVR pathogenesis.
Main Methods:
- Two patients underwent 23G revitrectomy with allogeneic PC for persistent macular holes.
- Clinical outcomes and PVR development were monitored closely post-operatively.
Main Results:
- Both patients exhibited pronounced PVR within days of the procedure, despite no prior risk factors.
- The development of PVR was temporally linked to the use of allogeneic PC.
Conclusions:
- Allogeneic PC may be an etiological factor in the rapid development of PVR after macular hole surgery.
- Further research is needed to understand the risks associated with allogeneic PC in ophthalmic procedures.
