Early and Pronounced PVR Reaction After Revitrectomy With Allogeneic Platelet Concentrate in Persistent Macular Hole

We report two cases of pronounced development of proliferative vitreoretinopathy (PVR) within a few days after 23G revitrectomy with allogeneic platelet concentrate (PC) in persistent macular hole in 2023-2024. None of the cases had relevant risk factors for PVR development such as intraoperative retinal tears. Because the revitrectomy with PC was performed as a no-touch technique after a previous uncomplicated vitrectomy, it is suspected that PC was the etiological factor. Many findings from previous studies indicate that the same growth factors that are secreted by the platelets and that are thought to have a positive effect on the closure of the macular foramina were also responsible for the development of PVR. Vitrectomy with PC-usually performed with autologous PC-is considered a safe standard procedure for the treatment of large and persistent macular holes. Why such a pronounced and early PVR reaction occurred in these two cases is unclear. One possible reason could be the use of allogeneic PC in our cases. To the best of our knowledge, there are no reported cases of this kind.