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Assessing Recurrent Acute Rhinosinusitis Development in Posttransplant Patients: A Study on Sinus Surgery Necessity.
Estephania Candelo1,2, Anyull Dayanna Bohorquez-Caballero1, Angela M Donaldson1
1Department of Otolaryngology and Head-Neck Surgery Mayo Clinic Jacksonville Florida USA.
OTO Open
|January 12, 2026
Summary
Recurrent acute rhinosinusitis (RARS) affects nearly 10% of transplant recipients (TR). Pre-existing conditions like rheumatoid arthritis increase RARS risk, but surgery is rarely needed.
Area of Science:
- Otolaryngology
- Immunology
- Transplant Medicine
Background:
- Recurrent acute rhinosinusitis (RARS) significantly impairs quality of life.
- Transplant recipients (TR) face heightened vulnerability to sinonasal conditions.
- Current management guidelines for RARS in TR are lacking.
Purpose of the Study:
- To determine the prevalence of RARS in transplant recipients.
- To identify risk factors associated with RARS development post-transplant.
- To assess the need for surgical intervention for RARS in this population.
Main Methods:
- Retrospective cohort study of 1116 patients from 2017-2022.
- Patients were categorized by RARS diagnosis and sinus surgery frequency.
- Logistic regression analysis identified odds ratios for RARS development.
Main Results:
- 9.95% of transplant recipients developed RARS.
- Pre-transplant asthma, viral infections, and rheumatoid arthritis (RA) were more common in RARS patients.
- RA, neutropenia, and mantle cell lymphoma increased RARS likelihood post-transplant.
Conclusions:
- This study is the first to examine RARS incidence and predictive factors in TR.
- Pre-transplant comorbidities increase RARS risk, but not necessarily the need for surgery.
- RARS management in TR requires further investigation, with a low threshold for surgical intervention.
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