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Precentral Gyrus Connectivity in Auditory Verbal Hallucinations: A Resting-State Functional MRI Study.

Vyara Zaykova1, Ferihan Popova1, Sevdalina Kandilarova2

  • 1Department of Anatomy, Histology and Embryology, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria.

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Summary

Schizophrenia patients with auditory verbal hallucinations show altered brain connectivity in the precentral gyrus. These functional connectivity (FC) changes, particularly in the right precentral gyrus (PCG), may indicate neurobiological pathways linked to schizophrenia.

Keywords:
auditory verbal hallucinationsfunctional magnetic resonance imagingprecentral gyrusschizophrenia

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Brain Imaging

Background:

  • Schizophrenia is a complex mental disorder.
  • Auditory verbal hallucinations (AVH) are a common symptom.
  • Understanding the neural basis of AVH is crucial.

Purpose of the Study:

  • To investigate functional connectivity (FC) of the precentral gyrus (PCG) in schizophrenia patients with AVH.
  • To compare FC patterns between patients and healthy controls (HC).

Main Methods:

  • Resting-state functional magnetic resonance imaging (fMRI) was used.
  • 105 subjects participated: 42 schizophrenia patients with AVH and 63 HC.
  • Bilateral PCG FC was analyzed comparatively.

Main Results:

  • Increased FC between the right PCG and frontal cortex, SMA, and ACC in patients vs. HC.
  • Decreased FC between the right PCG and lingual gyrus/occipital regions in patients.
  • Altered FC patterns were observed for the left PCG as well, showing both increased and decreased connectivity in specific brain regions.

Conclusions:

  • Schizophrenia patients exhibit lateralized impairments in PCG functional connectivity.
  • These FC alterations may contribute to the neurobiology of schizophrenia and hallucination proneness.