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Association between asthma and myopia: the NHANES database and Mendelian randomization analysis.
Ya-Jing Zheng1, Ji-Fa Kuang1, Fei-Lan Chen1
1Hainan Eye Hospital and Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou 570311, Hainan Province, China.
International Journal of Ophthalmology
|January 12, 2026
Summary
Asthma is significantly associated with myopia, and this study confirms a causal link. These findings have public health implications for managing both conditions.
Area of Science:
- Ophthalmology and Respiratory Medicine
- Genetic Epidemiology
- Public Health
Background:
- Asthma and myopia are prevalent conditions with potential shared risk factors.
- Understanding the etiological relationship between asthma and myopia is crucial for effective public health strategies.
Purpose of the Study:
- To investigate the association and causality between asthma and myopia using population data and genetic methods.
- To assess asthma as a risk factor for myopia development.
Main Methods:
- Utilized data from 8,460 subjects (1,676 myopia cases) from the National Health and Nutrition Examination Survey (NHANES) 2005-2008.
- Employed association analyses, risk stratification, and receiver operating characteristic (ROC) curve analysis.
- Performed Mendelian randomization (MR) analysis with sensitivity and directionality tests to establish causality.
Main Results:
- Asthma was significantly associated with myopia (OR=1.31, 95% CI=1.07-1.62, P=0.0133), indicating it as a risk factor.
- MR analysis confirmed a statistically significant causal relationship between asthma and myopia (P<0.05).
- Sensitivity analyses supported the robustness and unidirectional causality of the findings.
Conclusions:
- A significant association and causality exist between asthma and myopia.
- These findings underscore the importance of considering asthma in myopia prevention and management.
- Results provide valuable insights for public health policy and clinical practice.
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