Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

796
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
796
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

670
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
670
Hormones Regulating Blood Glucose01:16

Hormones Regulating Blood Glucose

6.4K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
6.4K
Oral Hypoglycemic Agents: Glinides01:06

Oral Hypoglycemic Agents: Glinides

585
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
585
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

2.1K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
2.1K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

4.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Heterogeneous domain adaptation survival analysis with partially observed outcomes via dictionary learning and distribution alignment.

Journal of biomedical informatics·2026
Same author

Mechanical circulatory support as a bridge to cancer therapy in patients with end stage heart failure: a single center experience.

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs·2026
Same author

A Wavelet AI Algorithm to Automatically Identify Postprandial Glucose Responses From Continuous Glucose Monitoring Profiles in People Without Diabetes.

Journal of diabetes science and technology·2026
Same author

Mental Health and Substance Use Disorders in Advanced Heart Failure Patients Undergoing VAD Implantation and Cardiac Transplantation: How Much do We Know?

Current cardiology reviews·2026
Same author

Machine Learning Models for Posttransplant Lymphoproliferative Disorder (PTLD) Risk Prediction in Thoracic Transplantation.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same author

Surgically tunneled femoral IABP with Dacron graft: novel technique to facilitate rehabilitation before and after cardiac surgery.

Indian journal of thoracic and cardiovascular surgery·2025

Related Experiment Video

Updated: Jan 13, 2026

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
07:30

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion

Published on: May 10, 2018

9.7K

Determining Causes of Insulin-Induced Hypoglycemia Using an Electronic-Based Trigger.

Kamil Evy A Bantol1, Yingchao Zhong1, Joanne Bruno2

  • 1Department of Medicine, NYU Langone Health, New York, NY.

American Journal of Medical Quality : the Official Journal of the American College of Medical Quality
|January 12, 2026
PubMed
Summary

Hypoglycemia, low blood glucose, is a common inpatient harm. This study identified insulin dosing errors and failure to stop insulin as key causes, requiring multifaceted solutions for prevention.

Keywords:
clinical decision supportelectronic triggersinpatient hypoglycemiainsulinquality improvement

More Related Videos

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.3K
Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
08:32

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

Published on: January 4, 2018

10.8K

Related Experiment Videos

Last Updated: Jan 13, 2026

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
07:30

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion

Published on: May 10, 2018

9.7K
Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.3K
Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
08:32

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

Published on: January 4, 2018

10.8K

Area of Science:

  • Internal Medicine
  • Clinical Pharmacy
  • Patient Safety

Background:

  • Hypoglycemia (blood glucose < 70 mg/dL) is a frequent medication-related harm in hospitalized patients.
  • Identifying and analyzing causes of hypoglycemia is crucial for improving patient safety.

Purpose of the Study:

  • To develop and validate an electronic trigger for identifying hypoglycemic events in hospitalized patients.
  • To analyze the root causes of insulin-mediated hypoglycemia.

Main Methods:

  • An electronic trigger was developed and validated through a multistep process.
  • 111 hypoglycemic events were identified between January 1 and December 31, 2023.
  • Qualitative analysis was performed on the identified hypoglycemic events.

Main Results:

  • The most common cause of hypoglycemia was related to insulin orders, including excessive starting/adjustment doses and failure to discontinue insulin.
  • Changes in dietary status and hyperkalemia treatment also emerged as contributing factors.
  • Multiple causative etiologies were identified, highlighting the complexity of hypoglycemia prevention.

Conclusions:

  • Preventing hypoglycemia in hospitalized patients necessitates multifaceted strategies.
  • Educational interventions for healthcare providers prescribing insulin are recommended.
  • Addressing insulin dosing and discontinuation protocols is essential for reducing hypoglycemic events.