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Injectable P24-Si-CaP/GelMA composite hydrogel for repairing bone defects.

Zhengye Zhang1, Huaying Wu2, Songrui Zhang1

  • 1Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China. wangxintao@hrbmu.edu.cn.

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This study developed an injectable P24-Si-CaP/GelMA hydrogel for bone repair. The enhanced material shows excellent biocompatibility and promotes significant new bone formation in vivo.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Severe bone defects present significant clinical challenges.
  • Existing Si-CaP materials have limitations in application convenience and degradability.
  • There is a need for advanced injectable scaffolds for bone defect repair.

Purpose of the Study:

  • To develop an injectable, light-curable P24-Si-CaP/GelMA composite hydrogel.
  • To enhance the osteogenic capacity of Si-CaP material via P24 peptide grafting.
  • To evaluate the biocompatibility and bone regeneration potential of the novel hydrogel.

Main Methods:

  • Fabrication of P24-Si-CaP/GelMA composite hydrogel.
  • Characterization of material properties (gelation, mechanical strength, porosity, hydrophilicity).
  • In vitro assessment of rat bone marrow mesenchymal stem cell (rBMSC) response and osteogenic differentiation.
  • In vivo evaluation of bone regeneration in a rat cranial defect model using micro-CT and histological analysis.

Main Results:

  • The P24-Si-CaP/GelMA hydrogel (20% mass ratio) demonstrated optimal gelation, mechanical strength, porosity, and hydrophilicity.
  • In vitro studies showed enhanced rBMSC migration, osteogenic differentiation, and mineralization with no cytotoxicity.
  • In vivo results indicated significantly higher new bone formation and defect closure in the P-Si/G group compared to controls after 8 weeks.

Conclusions:

  • The injectable P24-Si-CaP/GelMA hydrogel is biocompatible and osteoinductive.
  • The P-Si/G hydrogel promotes effective bone regeneration in vivo.
  • This composite hydrogel represents a promising injectable scaffold for bone tissue engineering applications.