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Related Concept Videos

Phase I Oxidative Reactions: Overview01:19

Phase I Oxidative Reactions: Overview

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Phase I biotransformation, or functionalization, is a crucial chemical process that converts drugs and other xenobiotics into more water-soluble forms, facilitating expulsion from the body. It involves oxidative, reductive, and hydrolytic reactions that add or unveil polar functional groups on lipophilic substrates. Key players in phase I reactions are the mixed-function oxidases. Situated in liver cell microsomes, these enzymes predominantly carry out drug metabolism. They require molecular...
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Related Experiment Video

Updated: Jan 13, 2026

Characterization of Electrode Materials for Lithium Ion and Sodium Ion Batteries Using Synchrotron Radiation Techniques
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From Failure to Design: Modulating Phase Transitions and Oxygen Release in Ni-Rich Cathodes.

Yunshan Zheng1, Yijing Liu1, Nengzhan Zheng1

  • 1Guangdong Provincial Key Laboratory of Thermal Management Engineering & Materials, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.

Advanced Materials (Deerfield Beach, Fla.)
|January 12, 2026
PubMed
Summary

This review shifts focus from suppressing structural instability in nickel-rich layered oxide cathodes for lithium-ion batteries to controlling it. Controlled features like spinel domains and oxygen vacancies enhance performance and stability.

Keywords:
Ni‐rich cathodesadvanced regulation strategiesoxygen vacanciesspinel phase transitionstructure‐property relationships

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Area of Science:

  • Materials Science
  • Electrochemistry
  • Battery Technology

Background:

  • Nickel-rich layered oxides (LiNi$_{x}$Co$_{y}$Mn$_{z}$O$_{2}$) are key for high-energy-density lithium-ion batteries (LIBs).
  • Structural instability, phase transitions, and oxygen vacancies (OVs) traditionally hinder their commercialization due to capacity fading and voltage decay.
  • Current strategies focus on suppressing these detrimental features.

Purpose of the Study:

  • To present a paradigm shift in understanding and utilizing structural features in Ni-rich cathodes.
  • To explore the dual roles of localized spinel domains and oxygen vacancies in enhancing battery performance.
  • To summarize advanced strategies for precise manipulation of phase transitions and defect chemistry.

Main Methods:

  • Review of conventional and advanced strategies for cathode material stabilization.
  • Analysis of the roles of localized spinel domains and oxygen vacancies.
  • Emphasis on advanced characterization (in situ/operando), computational modeling, and machine learning.

Main Results:

  • Localized spinel domains improve Li$^{+}$ diffusion and buffer stress.
  • Regulated oxygen vacancies enhance electrochemical kinetics and structural robustness.
  • Advanced strategies enable precise control over phase transitions and defect chemistry.

Conclusions:

  • Controlled utilization of structural features, rather than suppression, offers a new pathway for stabilizing Ni-rich cathodes.
  • Integrating advanced characterization, modeling, and machine learning is crucial for rational cathode design.
  • This approach addresses trade-offs between energy density, cycle life, and safety in next-generation LIBs.