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Updated: Jan 13, 2026

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
Chiral Thiourea Catalysts Containing Fluxional Groups: Synthesis of Fluorinated Chiral Building Blocks
Sermadurai Selvakumar1, Kajal P Somani1, Mukund P Sibi1
1Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108-6050, United States.
Abstract:
In this work, we describe the synthesis of a new class of chiral thiourea catalysts that feature a reactivity-enhancing pyridine group and a fluxional substituent that impacts selectivity. The synthesis of the chiral catalysts, which is modular, can be accomplished in four steps with good yields. We have evaluated the efficacy of the new catalysts in the conjugate addition of indoles to fluoroalkyl nitroalkenes. The reactions provide a variety of fluorinated chiral building blocks in 65-99% yield with 81-91% ee.
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