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25-Hydroxyvitamin D Deficiency Elevates the Risk of COPD Incidence and Mortality: A Large Population-Based
Ying Zhu1,2, Shengjie Zhao3, Chen Zhu4
1Senior Department of Pulmonary and Critical Care Medicine, the Eighth Medical Center of Chinese PLA General Hospital, Beijing, China
Chronic Obstructive Pulmonary Diseases (Miami, Fla.)
|January 12, 2026
Summary
Low vitamin D levels (25(OH)D deficiency) are linked to a higher risk of developing chronic obstructive pulmonary disease (COPD) and reduced survival. This highlights vitamin D
Area of Science:
- Pulmonary Medicine
- Endocrinology
- Nutritional Science
Background:
- The relationship between vitamin D (25(OH)D) levels and chronic obstructive pulmonary disease (COPD) requires further clarification.
- Existing research has not definitively established whether low vitamin D impacts COPD development or prognosis.
Purpose of the Study:
- To investigate the association between 25(OH)D concentrations and the incidence of COPD.
- To examine the relationship between 25(OH)D levels and COPD survival rates.
Main Methods:
- Utilized UK Biobank data from 328,855 participants for cross-sectional analysis of COPD prevalence.
- Employed logistic regression to assess the association between 25(OH)D levels and COPD prevalence.
- Conducted a prospective cohort study of 327,871 individuals, using Cox proportional hazards models to evaluate incident COPD and survival outcomes over a median follow-up of 15 years.
Main Results:
- COPD prevalence was significantly higher in individuals with 25(OH)D deficiency (OR 1.266).
- 25(OH)D deficiency was associated with increased COPD incidence (HR 1.874) and mortality (HR 1.598).
- Subgroup analyses indicated stronger associations in men, current smokers, and those not taking vitamin D supplements, with increased mortality risk in patients with depression.
Conclusions:
- 25(OH)D deficiency is significantly associated with both the incidence and survival of COPD.
- Findings support the potential role of vitamin D in COPD prevention and management.
- Further research into vitamin D supplementation as a preventive strategy for COPD is warranted.
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