Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Rapid Mechanically Activated channel transduces increases in plasma membrane tension into transient calcium influx.

The New phytologist·2026
Same author

Biointegration of a partially decellularized tracheal scaffold in a porcine model - preliminary results.

Scientific reports·2026
Same author

Community challenge towards consensus on characterization of biological tissue: C<sup>4</sup>Bio's first findings.

Journal of biomechanics·2025
Same author

Corvis<sup>ST</sup> biomechanical indices in the diagnosis of corneal stromal and endothelial disorders: an artificial intelligence-based comparative study.

The British journal of ophthalmology·2025
Same author

Development of a rabbit model of uterine rupture after caesarean section, histological, biomechanical and polarimetric analysis of the uterine tissue.

Reproduction & fertility·2025
Same author

Mechanics of pressurized cellular sheets.

Journal of the Royal Society, Interface·2025

Related Experiment Video

Updated: Jan 13, 2026

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter
05:14

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter

Published on: September 16, 2025

549

Assessment of Human Corneal Biomechanical Properties After Refractive Surgery With Inflation Test Using Optical

Benjamin Memmi1, Qian Wu2, Vincent Borderie1

  • 1Clinical Research Group 32, Transplantation et Thérapies Innovantes de la Cornée, Sorbonne Université, Hôpital National des 15-20, Paris, France.

Journal of Refractive Surgery (Thorofare, N.J. : 1995)
|January 12, 2026
PubMed
Summary

Refractive surgery weakens corneal biomechanical properties, reducing thickness and stiffness. Laser in situ keratomileusis (LASIK) had the greatest impact on corneal stiffness, highlighting the need to consider biomechanical changes post-surgery.

More Related Videos

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

3.4K
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
07:51

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

2.0K

Related Experiment Videos

Last Updated: Jan 13, 2026

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter
05:14

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter

Published on: September 16, 2025

549
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

3.4K
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
07:51

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

2.0K

Area of Science:

  • Ophthalmology
  • Biomechanical Engineering
  • Medical Imaging

Background:

  • Refractive surgery aims to correct vision by altering corneal shape.
  • Understanding the biomechanical changes in the cornea post-surgery is crucial for patient outcomes.
  • Optical coherence tomography (OCT) and inflation testing offer advanced methods for corneal analysis.

Purpose of the Study:

  • To evaluate the biomechanical properties of the cornea after refractive surgery.
  • To compare the effects of different refractive surgery techniques on corneal biomechanics.
  • To utilize inflation testing combined with OCT for precise biomechanical assessment.

Main Methods:

  • Human donor corneas were divided into healthy and treated groups (PRK, LASIK, small incision lenticule extraction).
  • Refractive treatments simulated -4.00 diopters myopia correction.
  • An inflation test was performed using an artificial anterior chamber, with intraocular pressure increased from 15 to 120 mm Hg.
  • Corneal deformation was monitored via OCT imaging to calculate corneal stiffness (Young's modulus).

Main Results:

  • All treated corneas showed significant reductions in thickness and Young's modulus compared to healthy corneas.
  • Mean corneal thickness decreased from 552.0 ± 5.9 µm (healthy) to 486.9 ± 14.0 µm (treated).
  • Young's modulus was significantly lower in treated corneas (14.2 ± 4.9 MPa) versus healthy corneas (22.9 ± 0.5 MPa).
  • LASIK resulted in the greatest reduction in corneal stiffness, while PRK had the least impact.

Conclusions:

  • Inflation testing with OCT provides precise assessment of biomechanical alterations post-refractive surgery.
  • Refractive surgery significantly impacts corneal biomechanical properties, reducing stiffness and thickness.
  • Consideration of biomechanical consequences is vital when selecting refractive surgical procedures.