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Updated: Jul 18, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
e-PRF with Xenograft for Immediate Implants in Aesthetic Zone -A Case Series
Purpose:
The aim of this novel study was to assess the effects of e-PRF (Extended PRF) along with xenograft and xenograft alone around the immediate implant in the aesthetic zone of stage III and stage IV periodontitis.
Materials And Methods:
The present study included Sixteen patients undergoing immediate dental implant placement in the anterior aesthetic region. Eight sites in each group were randomly assigned to either Group-I (e-PRF and xenograft around the immediate implant) or the Group-II (xenograft alone). The primary objective was the volumetric bone analysis, and the secondary objectives were to assess the wound healing index (WHI), probing depth, and Tissue biotype. Patients were evaluated at baseline, 3 months, 6 months, and 9 months for assessing WHI, probing depth, and Tissue biotype and at baseline, 9 months for volumetric bone analysis through CBCT.
Results:
Group 1 showed significant improvement in pocket probing depth, tissue biotype, and bone volume compared to Group 2 which showed minimal changes in probing depth, tissue biotype, and bone volume.
Conclusions:
The combination of e-PRF and xenograft around immediate implants in the aesthetic zone showed favourable outcomes in preserving hard and soft tissues, enhancing bone volume, and promoting wound healing. Hence e-PRF appears to be a valuable promising adjunct in immediate implant placement.

