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Updated: Jan 14, 2026
09:12
Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
Published on: January 30, 2014
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Microglial activation and RAS signaling: a dual-edged sword in neuroinflammation
Uma-Priya Priya Mohan1,2,3, Catalin M Filipeanu1, Eric Lazartigues1,2,3,4,5
1Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States.
Summary
Microglia
Area of Science:
- Neuroimmunology and neuroscience, focusing on the central nervous system's immune cells.
Background:
- Microglia, the CNS immune cells, maintain homeostasis but drive neuroinflammation when dysregulated.
- The renin-angiotensin system (RAS) critically modulates microglial activity.
- RAS components in microglia influence neuroinflammation and autonomic control.
Purpose of the Study:
- To review the expression, regulation, and function of RAS components in microglia.
- To explore how RAS signaling impacts microglial phenotypes and neuroinflammation.
- To discuss targeting microglial RAS for therapeutic benefit.
Main Methods:
- Literature review of studies on microglial RAS expression and function.
- Analysis of signaling pathways mediated by angiotensin receptors (AT1R, AT2R, Mas1R).
- Examination of the link between microglial RAS and neuroinflammation.
Main Results:
- Microglia express key RAS components, enabling local angiotensin signaling.
- AT1R activation promotes pro-inflammatory microglia, while AT2R/Mas1R promote homeostatic phenotypes.
- Dysregulated microglial RAS signaling contributes to chronic neuroinflammation.
Conclusions:
- Microglial RAS components are key regulators of neuroimmune activity.
- Targeting microglial RAS offers potential for treating neurodegenerative and cardiovascular diseases.
- Understanding microglial RAS provides novel therapeutic strategies for CNS disorders.
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