Related Experiment Video
Updated: Jan 14, 2026
Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
Published on: December 9, 2022
Role of Sepsis Markers as Potential Biomarkers for Inflammatory Bowel Disease: A Prospective Observational Study
Natsuki Ishida1, Shinya Tani1, Tomohiro Takebe1
1First Department of Medicine.
Goals:
This study aimed to investigate whether sepsis markers act as biomarkers of ulcerative colitis (UC) and Crohn's disease (CD).
Background:
The identification of noninvasive biomarkers for inflammatory bowel disease (IBD) is advantageous. This prospective observational study investigated whether the sepsis markers, interleukin-6 (IL-6), presepsin (PSEP), procalcitonin (PCT), and pentraxin 3 (PTX3), act as biomarkers of UC and CD.
Study:
Patients with UC or CD underwent endoscopy and assessment of the abovementioned sepsis markers, C-reactive protein (CRP), and leucine-rich alpha 2 glycoprotein (LRG). We prospectively examined the association of these markers with clinical activity and endoscopic scores, including the Mayo endoscopic subscore (MES) and simple endoscopic score for Crohn's disease (SES-CD).
Results:
Eighty-eight patients with UC and 49 patients with CD were enrolled. MES significantly correlated with LRG, CRP, IL-6, PSEP, and PTX3 in patients with UC. SES-CD significantly correlated with LRG, CRP, IL-6, and PTX3 in patients with CD. In UC, MES to 3 groups showed significantly higher LRG, CRP, and IL-6 levels than the MES 0 to 1 groups. The LRG, CRP, IL-6, PSEP, and PTX3 levels were significantly higher in the SES-CD ≥3 group than in the SES-CD ≤2 group.
Conclusions:
IL-6 in UC and IL-6, PSEP, and PTX3 in CD are potential biomarkers. Overall, our findings could promote better management of IBD.
Related Concept Videos
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:29Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
01:17Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...