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Bone Health in Young Lung Transplant Recipients: A Retrospective Study
Aviva Lerman1, Osnat Shtraichman1,2, Yaron Rudman1,3
1Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Respiration; International Review of Thoracic Diseases
|January 12, 2026
Summary
Young lung transplant recipients (LTRs) have high rates of low bone density and fractures. Early screening and treatment are crucial to prevent osteoporosis-related complications in this population.
Area of Science:
- Transplantation Medicine
- Bone Metabolism
- Pulmonology
Background:
- Osteoporosis is prevalent in end-stage lung disease and transplant recipients.
- Limited data exists on bone health in young lung transplant recipients (LTRs).
Purpose of the Study:
- To assess the prevalence and treatment of low bone density in young LTRs.
- To identify risk factors for post-transplant fractures.
Main Methods:
- Retrospective review of medical records for LTRs aged 18-50.
- Analysis of bone density scans, fracture incidence, and treatment data.
- Statistical analysis including hazard ratios for fracture prediction.
Main Results:
- 69% of LTRs underwent bone density scans, with 23% showing low bone density within the first year post-transplant.
- 23% of LTRs experienced post-transplant osteoporotic fractures, with a history of pre-transplant fractures predicting future events.
- 41% received osteoporosis treatment, mainly bisphosphonates, with 49% remaining fracture-free.
Conclusions:
- Young LTRs exhibit high rates of low bone density and fractures, including recurrent and severe cases.
- Early detection and intervention are essential for managing osteoporosis and reducing morbidity in this population.
