Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibody Structure and Classes01:25

Antibody Structure and Classes

Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Generation of immunoglobulin variable gene diversity.

Immunology today·2014
Same author

Activation of RegIIIbeta/gamma and interferon gamma expression in the intestinal tract of SCID mice: an innate response to bacterial colonisation of the gut.

Gut·2005
Same author

Interactions of commensal gut microbes with subsets of B- and T-cells in the murine host.

Vaccine·2004
Same author

Emerging links between hypermutation of antibody genes and DNA polymerases.

Nature reviews. Immunology·2002
Same author

Morphine inhibits mucosal antibody responses and TGF-beta mRNA in gut-associated lymphoid tissue following oral cholera toxin in mice.

Journal of immunology (Baltimore, Md. : 1950)·2001
Same author

Third complementarity-determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non-mutated genes.

Immunology·2001

Related Experiment Video

Updated: Jul 22, 2026

Generation of Murine Monoclonal Antibodies by Hybridoma Technology
09:42

Generation of Murine Monoclonal Antibodies by Hybridoma Technology

Published on: January 2, 2017

Idiotype sharing by murine strains differing in immunoglobulin allotype

P J Gearhart, J J Cebra

    Nature
    |March 16, 1978
    PubMed
    Summary

    No abstract available in PubMed .

    More Related Videos

    Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay
    06:15

    Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay

    Published on: September 7, 2018

    Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
    08:51

    Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

    Published on: March 15, 2019

    Related Experiment Videos

    Last Updated: Jul 22, 2026

    Generation of Murine Monoclonal Antibodies by Hybridoma Technology
    09:42

    Generation of Murine Monoclonal Antibodies by Hybridoma Technology

    Published on: January 2, 2017

    Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay
    06:15

    Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay

    Published on: September 7, 2018

    Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
    08:51

    Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

    Published on: March 15, 2019