Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

782
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
782
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

531
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
531

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brain protein burden is related to intravoxel incoherent motion: PET-MR imaging study.

Frontiers in neuroscience·2026
Same author

Predicting Autopsy-Confirmed Neuropathology across Clinical, Neuroimaging, and CSF Biomarkers using Machine Learning.

bioRxiv : the preprint server for biology·2026
Same author

An <i>APOE</i> *4-Informed Genomic Atlas of the X Chromosome in Alzheimer's Disease.

medRxiv : the preprint server for health sciences·2026
Same author

Effects of α-synuclein pathology on synaptic dysfunction and clinical outcomes in normal aging.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Plasma proteomic signatures of preclinical Alzheimer's disease in clinically unimpaired older adults.

Molecular neurodegeneration·2026
Same author

Plasma phosphorylated tau 217 detects amyloid-β in neuronal synuclein disease.

NPJ Parkinson's disease·2026
Same journal

Evidence for progressive neurodegeneration in iatrogenic cerebral amyloid angiopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Human brain connectome profiles mediate the relationship between pathology burden and clinical phenotypes in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Jan 14, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.2K

Biomarkers.

Julie E Oomens1, Theresa M Harrison2, Jeffrey L Dage3,4,5

  • 1Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|January 12, 2026
PubMed
Summary
This summary is machine-generated.

Integrating plasma pTau217 data with neuroimaging and demographic information enhances Alzheimer's disease research. This combined dataset facilitates understanding disease progression and pathology across diverse populations.

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

744

Related Experiment Videos

Last Updated: Jan 14, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.2K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

744

Area of Science:

  • Neuroscience
  • Biomarker Research
  • Data Integration

Background:

  • Data accessibility and interoperability are crucial for advancing Alzheimer's disease (AD) research.
  • Integrating diverse datasets, including plasma biomarkers and neuroimaging, enables novel hypothesis testing.
  • Publicly available data from the National Centralized Repository for Alzheimer's Disease and Related Dementia's (NCRAD) and Alzheimer's Disease Research Centers (ADRCs) offer valuable resources.

Purpose of the Study:

  • To integrate plasma pTau217 data from NCRAD with ADRC neuroimaging (SCAN initiative) and demographic data (National Alzheimer's Coordinating Center Uniform Data Set - NACC UDS).
  • To provide sample descriptives and present results from initial data explorations.
  • To establish a foundation for understanding the relationship between plasma biomarkers and neuroimaging in Alzheimer's disease and related dementias (ADRD).

Main Methods:

  • Data access was obtained through NACC and NCRAD procedures.
  • Focused on participants with available Quanterix Simoa HD-X Alzpath plasma pTau217 data.
  • Amyloid pathology was defined using centiloid values (>=20) from the SCAN initiative.
  • Data integration utilized NACC identifiers and visit age.
  • Spearman correlations assessed the association between plasma pTau217 and centiloid values.
  • Receiver Operating Characteristic (ROC) analyses evaluated amyloid classification performance.

Main Results:

  • Plasma pTau217 data was available for 927 participants.
  • In participants with available amyloid PET data (n=170), plasma pTau217 showed a strong correlation (Spearman's rho = 0.59) with centiloid values.
  • Quanterix pTau217 demonstrated high accuracy in classifying amyloid status (ROC AUC = 0.92, accuracy = 85%).
  • Tau PET data was also available for subsets of participants.

Conclusions:

  • The integration of SCAN PET and NCRAD plasma data creates a valuable resource for ADRD research.
  • The combined dataset already exhibits significant demographic diversity (36%).
  • Ongoing efforts within the SCAN initiative and the ADRC Consortium for Clarity in ADRD Research Through Imaging (CLARiTI) are expected to increase sample sizes and further enhance the resource.