Related Experiment Video
Updated: Jan 14, 2026
07:40
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
6.0K
Exploring the Association Between Autoimmune and Inflammatory Diseases and Uveitis
Nitesh Mohan1, Sunil K Srivastava2, Matthew J Schulgit1
1From the Cole Eye Institute (N.M., S.K.S., M.J.S., S.S.), Cleveland Clinic, Cleveland, Ohio, USA; Case Western Reserve University (N.M., M.J.S.), Cleveland, Ohio, USA; Cleveland Clinic Lerner College of Medicine (N.M., M.J.S., R.A.H.-A., S.S.) Cleveland, Ohio, USA.
American Journal of Ophthalmology
|January 12, 2026
Summary
Immune-mediated inflammatory diseases (IMIDs) significantly increase the risk of developing uveitis. This study found a strong, two-way association, highlighting the need for monitoring patients with either condition.
Area of Science:
- Ophthalmology
- Rheumatology
- Immunology
Background:
- Uveitis is an inflammatory eye condition with various causes.
- Immune-mediated inflammatory diseases (IMIDs) encompass a group of systemic autoimmune disorders.
- The relationship between IMIDs and uveitis requires further elucidation.
Purpose of the Study:
- To investigate the association between 12 IMIDs and the risk of developing uveitis.
- To determine the odds of prior IMID diagnoses in uveitis patients.
- To assess the risk of developing an IMID after a uveitis diagnosis.
Main Methods:
- Retrospective cohort and case-control study design.
- Utilized electronic health record data for analysis.
- Calculated relative risks (RR) and odds ratios (OR) with 95% confidence intervals (CIs).
Main Results:
- All 12 IMIDs were associated with a significantly increased risk of uveitis.
- Ankylosing spondylitis, juvenile idiopathic arthritis, and systemic vasculitis showed the highest uveitis risks.
- Patients with uveitis had increased odds of prior IMID diagnosis and increased risk of future IMID development.
Conclusions:
- There is a strong, bidirectional association between IMIDs and uveitis.
- Ophthalmologic evaluation is recommended for patients with IMIDs.
- Monitoring for IMID development is crucial for patients diagnosed with uveitis.
Related Concept Videos
01:29Autoimmune Disorders
1.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
1.4K
01:30Inflammatory Bowel Disease II: Crohn's Disease
945
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
945
01:17Chronic Bowel Disorders: Introduction
743
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
743
01:24T Cell Types and Functions
2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K
01:11Genome-wide Association Studies-GWAS
15.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.3K
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
882
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
882