Related Experiment Video
Updated: Jan 14, 2026
11:36
A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
Published on: April 28, 2016
9.7K
Unmasking malnutrition through soluble RAGE: A biomarker-guided insight from FRASNET
Sarah Damanti1, Clara Sciorati2, Amanda Avola2
1Vita Salute San Raffaele University, Milan, Italy; Internal Medicine Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Experimental Gerontology
|January 12, 2026
Summary
Higher soluble receptor for advanced glycation end-products (sRAGE) levels are linked to poorer nutritional status in older adults. This finding suggests sRAGE may help identify malnutrition risk, especially in women.
Area of Science:
- Geriatric Medicine
- Nutritional Science
- Biomarker Research
Background:
- Malnutrition is a common geriatric syndrome with serious health consequences.
- Inflammation plays a role in nutritional decline, but traditional markers are often insensitive.
- Soluble receptor for advanced glycation end-products (sRAGE) is an emerging biomarker for disease risk.
Purpose of the Study:
- To investigate the association between circulating sRAGE levels and nutritional status in community-dwelling older adults.
- To determine if sRAGE can serve as a biomarker for malnutrition risk in the elderly population.
Main Methods:
- Prospective observational study of 52 community-dwelling older adults within the FRASNET cohort.
- Assessment of serum sRAGE levels and nutritional status (Mini Nutritional Assessment Short Form) at two time points.
- Linear regression and ROC curve analysis to evaluate associations and diagnostic performance.
Main Results:
- Higher baseline sRAGE levels correlated with lower BMI, reduced calf circumference, and poorer MNA-SF scores.
- These associations were more significant in women.
- ROC analysis showed good diagnostic accuracy for malnutrition risk (AUC = 0.85) with an optimal sRAGE cut-off of 1362.5 pg/mL.
Conclusions:
- Elevated sRAGE levels are prospectively associated with adverse nutritional outcomes in older adults, particularly women.
- sRAGE shows potential as a valuable tool for the early detection of inflammation-related malnutrition risk.
