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Updated: Jan 14, 2026

Mouse Models of Epididymitis Induced by Pathogen-Associated Molecular Patterns
Published on: December 12, 2025
Immune-modulating medications: the masquerading culprit of epididymo-orchitis
David S Buchinsky1, Hari M Polenakovik2,3, Jonathan I Hakim1,3
1Wright State University Boonshoft School of Medicine, Dayton, Ohio, USA.
Abstract:
Immune checkpoint inhibitors (ICI) have revolutionised pharmacological chemotherapy for various malignant neoplasms. The side effects of ICIs are still being fully understood. We present a case of a male patient in his mid-50s with a history of metastatic renal cell carcinoma ultimately diagnosed with bilateral epididymo-orchitis (EO) following pembrolizumab maintenance treatment. Our report adds to the three identified cases of EO linked to immune checkpoint inhibitors. This rarely reported association should serve as a cautionary tale for future clinicians about the possible side effects of these immune-enhancing medications.
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