Hematological, biochemical and hormonal profiles in dogs with obesity-related metabolic disorder

Canine obesity-related metabolic disorder (ORMD) is a condition derived from human metabolic syndrome. Although there are several indicators shared between both species, such as obesity, hypertension, hyperglycemia, hypertriglyceridemia and hypercholesterolemia, the repercussions of canine ORMD are not clearly established. This study aimed to evaluate the suitability of canine ORMD indicators and their association with other paraclinical parameters. Obese dogs (body condition score 7-9, n=39) were included in this study and classified according to the literature in ORMD-positive or negative. Subsequently, they were evaluated for blood pressure, hematological, biochemical, hormonal and urine analysis. Discriminant capacity and cut-off values were determined for systolic blood pressure, glycemia, serum triglycerides and cholesterol. All ORMD-positive dogs showed hyperinsulinemia and hyperglycemia, with a homeostatic model assessment for insulin resistance mean value above the reference interval, which could reflect a certain insulin resistance status. Total cholesterol did not differ between groups, but serum triglycerides, as well as systolic blood pressure, tended to be higher in ORMD-positive dogs. Leukocyte count, lymphocyte count, total proteins and globulins were higher in ORMD-positive dogs, which could suggest an immune-inflammatory disorder in this group of patients. In conclusion, ORMD positive dogs developed insulin resistance and alterations in their hematological and protein profile towards a pro-inflammatory state. Total cholesterol concentration should be revised as a marker for ORMD.