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Updated: Jan 14, 2026
08:55
The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
Published on: November 30, 2016
17.1K
Cancer cachexia: molecular basis and therapeutic advances
Yuting Tan1,2, Rui Xue1,2, Yuwei Pan1,2
1School of Medicine, Chongqing University, Chongqing, PR China.
Signal Transduction and Targeted Therapy
|January 12, 2026
Summary
Cancer cachexia involves complex interactions between tumors and the body, disrupting metabolism and inflammation. Targeting these pathways offers promising therapeutic strategies for patients.
Area of Science:
- Oncology
- Metabolism
- Immunology
Background:
- Cancer cachexia affects 50-80% of cancer patients, significantly impacting morbidity.
- The progression of cancer cachexia is not fully understood at organismal, cellular, and molecular levels.
- Neoplastic cells and host interactions are critical in cancer cachexia pathogenesis.
Purpose of the Study:
- To explore target organs and regulatory roles in cancer cachexia.
- To examine macroenvironmental interactions and organismal crosstalk axes.
- To summarize cellular and molecular networks driving cancer cachexia.
Main Methods:
- Review of current literature on cancer cachexia.
- Analysis of systemic metabolic remodeling and inflammatory responses.
- Focus on cross-organismal, cellular, and molecular interactions.
Main Results:
- Systemic metabolic remodeling is a hallmark, modulating tumor microenvironment inflammation.
- Inflammatory responses disrupt energy metabolism in distant organs.
- A vicious cycle exacerbates cachexia through mediator secretion and signaling pathways.
Conclusions:
- Complex networks link metabolic reprogramming and inflammatory cascades in cancer cachexia.
- Targeting metabolic remodeling and inflammation shows therapeutic promise.
- Innovative strategies and clinical trials are underway to mitigate cancer cachexia.
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