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Updated: Jan 14, 2026

CRISPR/Cas9-mediated Targeted Integration In Vivo Using a Homology-mediated End Joining-based Strategy
Published on: March 12, 2018
Targeted delivery of genome editors in vivo
Wayne Ngo1,2,3, Jamie L Y Wu1,2,3, Kevin M Wasko1,4
1Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.
Abstract:
Genome editing has revolutionized the treatment of genetic diseases, yet the difficulty of tissue-specific delivery currently limits applications of editing technology. In this Review, we discuss preclinical and clinical advances in delivering genome editors with both established and emerging delivery mechanisms. Targeted delivery promises to considerably expand the therapeutic applicability of genome editing, moving closer to the ideal of a precise 'magic bullet' that safely and effectively treats diverse genetic disorders.
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