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Updated: Jan 14, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
Spontaneous somatic Pten loss contributes to functional heterogeneity of T cells
Allen Y Chen1,2,3, Alexander Y Rudensky4
1Division of Rheumatology, Department of Medicine, Hospital for Special Surgery, New York, NY, USA. yuyin.chen@nyulangone.org.
Abstract:
We found that healthy mice harbor T cells with heritable low Pten expression and that monoallelic Pten loss in CD4 T cells causes a bias in their differentiation toward T follicular helper cells during acute viral infection. These results suggest that somatically induced mono- or biallelic loss of expression of signaling-related genes in T cells can impact the quality of population-level T cell responses-without conspicuous pathological sequelae such as autoimmune and inflammatory manifestations or lymphomagenesis.
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