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The dynamics of mutational selection in cutaneous squamous carcinogenesis

Greta Skrupskelyte1, Joanna C Fowler2, Stefan Dentro2,3,4

  • 1Cambridge Stem cell Institute, University of Cambridge, Cambridge, UK.

Communications Biology
|January 12, 2026
PubMed
Summary

Identifying cancer-driving genes requires analyzing selection dynamics. This study in mice revealed distinct genetic pathways in skin cancer, highlighting the importance of examining normal tissue alongside tumors to pinpoint key mutations.

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