Pediatric meningioma and seizures: a single-center cohort study
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View abstract on PubMed
Summary
This summary is machine-generated.Pediatric meningiomas frequently cause seizures. Gross total resection (GTR) aids seizure control, but anti-seizure medication (ASM) use is inconsistent, highlighting a need for standardized management guidelines in children.
Area Of Science
- Pediatric neuro-oncology
- Neurosurgery
- Epileptology
Background
- Pediatric meningiomas are rare tumors, often presenting with seizures.
- Seizure outcomes and perioperative management strategies for pediatric meningiomas are not well-documented.
- Understanding seizure presentation and treatment efficacy is crucial for this population.
Purpose Of The Study
- To characterize seizure presentation in pediatric meningioma patients.
- To evaluate the use of anti-seizure medications (ASMs).
- To assess seizure outcomes after surgical resection in children with meningiomas.
Main Methods
- Retrospective chart review of pediatric patients (<18 years) diagnosed with meningioma (2014-2024).
- Inclusion of surgically treated (histologically confirmed) and conservatively managed (radiographically presumed) patients.
- Data extraction on seizure presentation, ASM use, tumor features, extent of resection (EOR), and seizure outcomes (Engel classification).
Main Results
- Sixteen pediatric patients (median age 15 years) were analyzed; 37.5% presented with seizures.
- Gross total resection (GTR) was achieved in 91.7% of surgically treated patients and 100% of those with seizures.
- At 3.5-year follow-up, 66.7% achieved Engel Class IA outcomes; ASM regimens varied, indicating a lack of standardized protocols.
Conclusions
- Seizures are a common presentation in pediatric meningioma.
- GTR appears beneficial for seizure control, but ASM management is heterogeneous.
- There is a need for consensus-based guidelines and further multicenter studies on pediatric meningioma seizure management.
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