Benchmarked Colorectal Cancer Outcomes in a Metropolitan Hospital: A 5-Year Review

Area of Science:

• Oncology
• Clinical Research
• Cancer Epidemiology

Background:

• Colorectal cancer (CRC) is a leading cause of cancer mortality globally.
• Prognostic factors significantly influence patient survival in CRC.
• This study focuses on survival outcomes and prognostic factors for CRC patients at Northern Hospital (2016-2021).

Purpose of the Study:

• To evaluate survival outcomes (Overall Survival and Progression-Free Survival) in colorectal cancer patients.
• To identify independent prognostic factors affecting survival in CRC.
• To conduct a subgroup analysis for patients with metastatic colorectal cancer.

Main Methods:

• Retrospective review of data from the Bowel Cancer Outcomes Registry (B-COR) and electronic patient records.
• Kaplan-Meier survival analysis for Overall Survival (OS) and Progression-Free Survival (PFS).
• Univariate and multivariate Cox proportional hazards analysis to determine independent prognostic factors.

Main Results:

• Median OS was 93.1 months; 5-year OS was 67.1%.
• Independent prognostic factors for survival included age, stage at diagnosis, abnormal CEA, and primary tumor resection.
• In metastatic CRC, curative-intent chemotherapy and metastasectomy improved survival; lung-only metastasis showed the best 5-year survival (46.0%).

Conclusions:

• Northern Hospital's CRC survival outcomes are comparable to international benchmarks.
• AJCC staging and CEA levels are crucial prognostic markers for risk stratification.
• Multimodal and curative-intent treatments significantly enhance survival, particularly in metastatic colorectal cancer, underscoring the need for early detection.