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Related Concept Videos

Obsessive-Compulsive Disorder01:28

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Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
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Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
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Related Experiment Video

Updated: Jan 14, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
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Black EquaLity in OCD NeuroGenomics (BELONG): Study Protocol.

Iasha J Williams1, Dalia Y Marquez2,3,4, Kara E Lopez-Lengowski5

  • 1Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA.

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
|January 13, 2026
PubMed
Summary

The Black EquaLity in OCD NeuroGenomics (BELONG) study aims to increase Black American representation in obsessive-compulsive disorder (OCD) genetic research. This initiative will identify OCD risk genes in diverse populations for precision medicine.

Keywords:
African ancestryBlackOCDexomegeneticgenomicobsessive‐compulsive disordertrio

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Area of Science:

  • Psychiatric Genetics
  • Neurogenomics
  • Population Genetics

Background:

  • Obsessive-compulsive disorder (OCD) affects 2%-3% of the population, with genetic factors contributing significantly to risk.
  • Current genomic studies for OCD predominantly feature participants of European ancestry, limiting the generalizability of findings.
  • There is a critical need to expand genetic research to underrepresented populations to understand OCD etiology and develop targeted therapies.

Purpose of the Study:

  • To establish the Black EquaLity in OCD NeuroGenomics (BELONG) study, collecting data from 1250 Black Americans with OCD.
  • To increase the representation of Black Americans in OCD genetic research.
  • To identify common and rare genetic variants associated with OCD risk in African ancestry populations.

Main Methods:

  • Collecting DNA and detailed clinical data from 1250 OCD cases of African ancestry.
  • Obtaining parental DNA samples for trio-based analyses and matched controls for case-control analyses.
  • Sequencing DNA using optimized methods to analyze both rare and common genome-wide variations and meta-analyzing data with existing OCD genomic studies.

Main Results:

  • The BELONG study is actively collecting data to address the underrepresentation of Black Americans in OCD genetic research.
  • This study will enable the examination of genome-wide variation to identify novel OCD risk genes.
  • Findings will contribute to a more comprehensive understanding of OCD genetics across diverse populations.

Conclusions:

  • The BELONG study is crucial for enhancing the generalizability of precision medicine discoveries in psychiatric genetics.
  • Increasing diversity in OCD genetic research is essential for developing effective, broadly applicable treatments.
  • This research will facilitate the identification of molecular targets for novel OCD therapeutics applicable to diverse populations.