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Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
Published on: March 29, 2024
Metabolic Stress and Immune Activation in Heart Failure With a Preserved Ejection Fraction
Ana Pereira1, Santiago Alvarez-Argote1, Isaac Meite1
1Department of Pathology, Feinberg School of Medicine and Center for Cardiovascular Innovation at the Heart Center, Northwestern University & Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Abstract:
Inflammation is triggered by imbalances to systemic and cellular metabolism. This occurs in the setting of cardiometabolic heart failure, for which low-grade inflammation is a commonly reported feature. In experimental models, immune cells are causal determinants in the pathophysiology of metabolic syndromes. Herein we discuss evidence for the contribution of metabolic stress to immune cell activation during cardiometabolic heart failure with preserved ejection fraction. We also discuss related therapeutic approaches along the way.
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