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Updated: Jan 14, 2026

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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Resistance to the KRASG12D Inhibitor MRTX1133 Is Associated with Increased Sensitivity to BET Inhibition

Daniel R Principe1,2, Jeffrey H Becker2,3, Anastasia E Metropulos2,3

  • 1Department of Medicine, Physician Scientist Training Program, University of Wisconsin, Madison, Wisconsin.

Molecular Cancer Therapeutics
|January 13, 2026
PubMed
Summary

KRASG12D inhibitors show limited efficacy in pancreatic cancer. Combining these with BET inhibitors overcomes resistance by targeting FOSL1 signaling, offering a promising therapeutic strategy for KRAS-mutated pancreatic ductal adenocarcinoma.

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