Glycyrrhizin's Potential to Modulate Feeding Behaviour by Neutralizing Reduced Feed Intake in Inflamed Arian Broilers

Area of Science:

• Veterinary Medicine
• Animal Physiology
• Pharmacology

Background:

• Arian broilers, a native Iranian breed, exhibit high susceptibility to metabolic issues triggered by lipopolysaccharide (LPS).
• Investigating natural compounds for mitigating LPS effects is crucial for poultry health.

Purpose of the Study:

• To evaluate the efficacy of glycyrrhizin in counteracting lipopolysaccharide (LPS)-induced physiological disruptions in Arian broilers.
• To assess the dose-dependent effects and administration routes of glycyrrhizin.

Main Methods:

• A controlled trial involving 100 Arian broilers was conducted with various glycyrrhizin and LPS administration routes (intracerebroventricular and intraperitoneal).
• Key parameters monitored included feeding behavior, feed intake, and cloacal temperature over an 8-hour period.
• Dose-response assessments and interaction studies between glycyrrhizin and LPS were performed.

Main Results:

• LPS challenge induced biphasic thermoregulation changes (hypothermia then hyperthermia) and reduced feed intake.
• Glycyrrhizin administration via both intraperitoneal and intracerebroventricular routes dose-dependently increased feed intake.
• Co-administration of glycyrrhizin and LPS at optimal doses completely prevented LPS-induced disturbances.

Conclusions:

• Glycyrrhizin effectively counteracts LPS-induced thermoregulatory and feeding disturbances in Arian broilers via rapid-acting mechanisms.
• The observed physiological improvements suggest anti-inflammatory actions, though direct molecular evidence requires further investigation.