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Oxytocinergic Signaling in Zebrafish: Translational Perspectives for Autism Spectrum Disorder
Géssica Peres1, Melissa Talita Wiprich2,3, Darlan Gusso3
1Programa de Pós-Graduação em Medicina e Ciências da Saúde, Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Journal of Neurochemistry
|January 13, 2026
Summary
Zebrafish models offer insights into oxytocin signaling and its role in neurodevelopmental disorders like Autism Spectrum Disorder. This research explores oxytocin
Area of Science:
- Neuroscience
- Developmental Biology
- Pharmacology
Background:
- Oxytocin system alterations are linked to cognitive and behavioral deficits in neurodevelopmental conditions, including Autism Spectrum Disorder (ASD).
- Oxytocin, a hypothalamic neuropeptide, is crucial for social cognition and behavior.
- The therapeutic potential of oxytocin for neurodevelopmental disorders is under investigation, but its signaling mechanisms require further elucidation.
Purpose of the Study:
- To review the mechanisms of oxytocin signaling.
- To discuss the utility of zebrafish as a model organism for studying oxytocin's effects in the context of neurodevelopmental disorders, particularly ASD.
Main Methods:
- Literature review of oxytocin signaling pathways.
- Analysis of zebrafish neurochemical pathways and behavioral repertoire.
- Evaluation of existing research on zebrafish as a model for ASD-related neurobiology.
Main Results:
- Zebrafish possess conserved neurochemical pathways relevant to oxytocin signaling.
- The species exhibits complex social behaviors and a broad behavioral repertoire, making it suitable for modeling neurodevelopmental alterations.
- Current findings support the use of zebrafish for investigating oxytocin's role in ASD.
Conclusions:
- Zebrafish represent a valuable model for understanding oxytocin system function in neurodevelopmental disorders.
- Further research using zebrafish can elucidate oxytocin's mechanisms and therapeutic potential for conditions like ASD.
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