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[A «Trojan horse» for glioblastoma: targeted aptamer delivery strategy]
S A Pavlova1,2, F M Dzarieva1,2, G V Pavlova1,2
1Institute of Higher Nervous Activity and Neurophysiology, Moscow, Russia.
Abstract:
Gliomas are among the most aggressive primary brain tumors characterized by extremely poor prognosis. Despite standard therapy including surgery, radiotherapy and chemotherapy, median survival remains extremely low. The main obstacles to effective treatment are tumor heterogeneity, blood-brain barrier and difficult targeted delivery of therapeutic agents. This review examines potential of aptamers as an alternative to traditional approaches. A particular attention is paid to mechanisms of aptamer cross-breeding and cellular internalization, particularly receptor-mediated endocytosis. The last one is essential for efficient penetration of these molecules into tumor cells. Analysis of current data demonstrates that aptamers specific to glioma cell surface markers not only provide highly accurate tumor imaging but also open new opportunities for target delivery of therapeutic agents. It is a promising tool for personalized glioblastoma therapy.
Insights
Aptamers offer a promising new approach for treating aggressive gliomas. These molecules can target glioma cells, enabling accurate imaging and drug delivery for personalized glioblastoma therapy.
Area of Science:
- Neuro-oncology
- Biotechnology
- Molecular Medicine
Background:
- Gliomas are aggressive primary brain tumors with poor prognosis despite standard treatments.
- Key challenges include tumor heterogeneity, the blood-brain barrier, and targeted drug delivery.
Purpose of the Study:
- To review the potential of aptamers as an alternative therapeutic strategy for gliomas.
- To explore aptamer mechanisms for cellular internalization and targeted delivery.
Main Methods:
- Review of current literature on aptamer applications in glioma research.
- Analysis of aptamer mechanisms, including cross-breeding and receptor-mediated endocytosis.
- Examination of aptamers targeting glioma cell surface markers.
Main Results:
- Aptamers show potential for accurate glioma imaging.
- Aptamers facilitate targeted delivery of therapeutic agents across the blood-brain barrier.
- Receptor-mediated endocytosis is crucial for aptamer internalization into tumor cells.
Conclusions:
- Aptamers represent a promising tool for personalized glioblastoma therapy.
- Targeted aptamer delivery overcomes major obstacles in current glioma treatment.
- Further research into aptamer-based strategies is warranted for improved patient outcomes.
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