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Updated: Jan 14, 2026

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing
Published on: August 24, 2017
Clinical utility of serial plasma cell-free DNA metagenomic next-generation sequencing assays
Ishminder Kaur1, Bennett Shaw2, Ashrit Multani3
1Division of Infectious Diseases, Department of Pediatrics, David Geffen School of Medicine, https://ror.org/046rm7j60University of California, Los Angeles, CA, USA.
Abstract:
This single center retrospective observational study of serial plasma metagenomic next-generation sequencing testing shows that >95% of serial testing was without meaningful clinical impact. Only 5/173 cases were adjudicated as having significant clinical impact.
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