Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomics02:02

Genomics

39.6K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.6K
RNA-seq03:21

RNA-seq

11.7K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
11.7K
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

4.6K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
4.6K
Multicompartment Models: Overview01:14

Multicompartment Models: Overview

497
Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
497
Multi-input and Multi-variable systems01:22

Multi-input and Multi-variable systems

384
Cruise control systems in cars are designed as multi-input systems to maintain a driver's desired speed while compensating for external disturbances such as changes in terrain. The block diagram for a cruise control system typically includes two main inputs: the desired speed set by the driver and any external disturbances, such as the incline of the road. By adjusting the engine throttle, the system maintains the vehicle's speed as close to the desired value as possible.
In the absence of...
384
Multiple Allele Traits01:49

Multiple Allele Traits

37.9K
The Concept of Multiple Allelism
37.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Blockchain-based Framework for Generating and Managing Unlearnable Examples for Enhancing Data Privacy and Access Control.

Journal of visualized experiments : JoVE·2025
Same author

Immunomodulatory role of natural products in treating rheumatoid arthritis.

International immunopharmacology·2025
Same author

Effect of Orthodontic Force on Gingival Blood Flow Measured by Laser Speckle Contrast Imaging: A Randomised Controlled Trial.

International dental journal·2025
Same author

Shu-Feng-Jie-Biao Formula Ameliorates Influenza A Virus-Induced Acute Lung Injury by Inhibiting NF-κB and ERK MAPK Signaling Pathways.

Infection and drug resistance·2025
Same author

Shared diagnostic biomarkers and underlying mechanisms between endometriosis and recurrent implantation failure.

Frontiers in endocrinology·2025
Same author

The matrix stiffness is increased in the eutopic endometrium of adenomyosis patients: a study based on atomic force microscopy and histochemistry.

European journal of histochemistry : EJH·2024
Same journal

STED: flexible cross-modal topic modeling infers cell-type-specific regulatory landscapes from bulk epigenomics.

Briefings in bioinformatics·2026
Same journal

A knowledge-guided deep learning framework for quantitative nucleic acid testing.

Briefings in bioinformatics·2026
Same journal

Optimal transport for label transfer in single-cell multi-omics integration.

Briefings in bioinformatics·2026
Same journal

Continuous multi-omics pathway enrichment analysis resolves hidden functional heterogeneity.

Briefings in bioinformatics·2026
Same journal

Evaluating completeness, coherence, and consistency of genome-scale function annotations.

Briefings in bioinformatics·2026
Same journal

Transformers for single-cell RNA sequencing: a survey.

Briefings in bioinformatics·2026
See all related articles

Related Experiment Video

Updated: Jan 14, 2026

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

2.0K

Adaptive multi-view information bottleneck for multi-omics data clustering.

Zhen Tian1,2, Xiaojiao Wei3, Zhengzheng Lou2

  • 1Yangtze Delta Region Institute (Quzhou), University of Electronic Science and Technology of China, No. 1, Chengdian Road, Kecheng District, Quzhou 324000, China.

Briefings in Bioinformatics
|January 13, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces scAMVIB, a novel framework for multi-omics data clustering. It effectively integrates diverse omics data, adaptively weighting each source to improve cell-type identification and biological insights.

Keywords:
adaptive weighting mechanismsmulti-omics data clusteringmulti-view information bottleneck

More Related Videos

Visualization and Quantification of High-Dimensional Cytometry Data using Cytofast and the Upstream Clustering Methods FlowSOM and Cytosplore
06:01

Visualization and Quantification of High-Dimensional Cytometry Data using Cytofast and the Upstream Clustering Methods FlowSOM and Cytosplore

Published on: December 12, 2019

8.9K
Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.7K

Related Experiment Videos

Last Updated: Jan 14, 2026

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

2.0K
Visualization and Quantification of High-Dimensional Cytometry Data using Cytofast and the Upstream Clustering Methods FlowSOM and Cytosplore
06:01

Visualization and Quantification of High-Dimensional Cytometry Data using Cytofast and the Upstream Clustering Methods FlowSOM and Cytosplore

Published on: December 12, 2019

8.9K
Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.7K

Area of Science:

  • Computational Biology
  • Bioinformatics
  • Genomics

Background:

  • Single-cell sequencing enables detailed gene expression analysis and cellular heterogeneity studies.
  • Multi-omics data integration is crucial for advanced cell clustering and identification.
  • Current methods face challenges in effectively integrating and weighting complementary multi-omics information.

Purpose of the Study:

  • To develop an adaptive multi-view clustering framework for multi-omics data.
  • To address challenges in integrating complementary information and allocating appropriate weights in multi-omics data analysis.
  • To enhance cell-type identification and biological interpretation through improved clustering.

Main Methods:

  • Proposed an Adaptive Multi-View clustering framework with the Information Bottleneck principle (scAMVIB).
  • Learned multi-view omics representations capturing inter-omics associations and omics-specific patterns with adaptive weight allocation.
  • Utilized similarity network fusion for integrated omics features and omics-specific representations, processed via a multi-view information bottleneck clustering framework.
  • Employed maximum entropy regularization for adaptive view weight assignment based on information content.
  • Achieved final cell partitions through sequential iterative optimization.

Main Results:

  • scAMVIB effectively captures both inter-omics associations and omics-specific patterns.
  • Adaptive weight allocation enhances the integration of complementary information from different omics data.
  • The framework leverages cross-view complementarity to improve data representations.
  • Comprehensive experiments show scAMVIB's strong performance in clustering tasks.
  • The method maintains biological interpretability alongside clustering accuracy.

Conclusions:

  • scAMVIB provides a robust and interpretable approach for multi-omics data clustering.
  • The adaptive weighting strategy is key to effectively integrating diverse omics datasets.
  • This framework advances cell-type identification and the study of biological processes using multi-omics data.